Population-Based Medicine


Patient Reported Outcome Measurement System (PROMIS)

Practice-based data collection is widely used across clinical settings for monitoring diseases, conditions, health services, and device safety. These databases are critical to the development of a more complete knowledge base of any field of medicine.

Patients Receiving Integrative Medicine Interventions Effectiveness Registry (PRIMIER)

Centers participating in PRIMIER are regularly collecting patient-reported outcomes and extracted electronic health record data into a large dataset. This registry utilizes the Patient-Reported Outcomes Measurement System (PROMIS) developed by the National Institutes of Health (NIH), which is a web-based survey that collects patient-reported data on key health symptoms and health-related quality of life, including pain, depression, fatigue, and physical function. These data, grouped by health condition, are easily matched with data regarding laboratory tests, patient functionality, and other measures routinely collected in patients’ medical records.

By clustering participants at the multiple clinical sites with the same medical condition, researchers are able to conduct innovative research by comparing the impact of various integrative therapies on patient-reported and clinical outcomes.  PRIMIER also provides much-needed clinical information on which real-world approaches to common clinical problems appear most effective, and which appear ineffective.  In essence, PRIMIER provides the framework for discovering the “best practices” of integrative medicine.

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